IBF middleweight titleholder Jacobs beat Serhiy Derevianchenko via split decision in October to take the vacant belt, while Canelo will put his WBA (Super), WBC, The Ring and lineal middleweight belts on the line.
Boxers turned ESPN analysts Timothy Bradley and Juan Manuel Marquez also backed Alvarez to triumph on Saturday, albeit by knockout and split decision, respectively.
Jacobs, 32, has lost only twice in his career and is one of only five fighters who have gone the distance against former WBA (Super), WBC, and IBO middleweight champion Golovkin (a unanimous-decision loss).
Former super middleweight world champion Badou Jack spoke to the Mayweather Boxing Channel (some language NSFW) and said he was rooting for Jacobs.
Jacobs will attempt to become the first middleweight to beat Alvarez in Vegas on Saturday, and he'll continue to fight against the odds as the experts lean in favour of Canelo to take the victory.